Across TCGA patient cohorts, C8orf86 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C8orf86-associated genes across cancer lineages are eEF2, ERK2, and GAPDH. Each is linked with C8orf86 in more than 1 cancer types. Because this analysis shows association rather than direction, both C8orf86-to-partner and partner-to-C8orf86 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf86→partner) and Y-score (partner→C8orf86) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.548	+3.169	.002	.018	3	1
UCEC	ERK2 →	+0.261	+2.321	.006	.035	3	1
UCEC	GAPDH →	+0.566	+2.321	.035	.035	3	1
UCEC	ACC1 →	+0.393	+2.321	.031	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.203	-3.169	.016	.019	3	1
UCEC	JNK2 →	+0.203	+2.321	.042	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

C8orf86 survival (RNA) · tumor vs normal (RNA) · all C8orf86 data types