Across TCGA pan-cancer cohorts, C8orf86 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of C8orf86’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C8orf86 RNA is repressed in tumor relative to normal tissue. In most cancer types C8orf86 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
KIRC, BRCA, and PRAD are the cancer types where C8orf86 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C8orf86 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.