C8orf74

Across TCGA cell cohorts, C8orf74 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C8orf74-associated genes across cancer lineages are PGK2, OR7E24, and KRTAP5-4. Each is linked with C8orf74 in more than 1 cancer types. Because this analysis shows association rather than direction, both C8orf74-to-partner and partner-to-C8orf74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGK2 grouped by C8orf74-low versus C8orf74-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf74→partner) and Y-score (partner→C8orf74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	2
SOFT_TISSUE	OR7E24 →	+0.029	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRTAP5-4 →	+0.032	+5.369	<.001	.004	3	1
LARGE_INTESTINE	ADGRL4 →	+0.067	+3.832	<.001	.001	3	1
LUNG_NSCLC_LUAD	MYF5 →	+0.995	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	MT1HL1 →	+0.130	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PGK2 by C8orf74 expression — SOFT_TISSUE

Explore this box plot interactively →