C8orf58

Across TCGA patient cohorts, C8orf58 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C8orf58-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with C8orf58 in more than 1 cancer types. Because this analysis shows association rather than direction, both C8orf58-to-partner and partner-to-C8orf58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by C8orf58-low versus C8orf58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf58→partner) and Y-score (partner→C8orf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.115	-1.986	.011	.032	3	1
UCEC	EGFR_pY1068 →	-0.289	-2.700	.010	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.189	-1.986	.012	.032	3	1
UCEC	NDRG1_pT346 →	-0.456	-2.000	.039	.032	3	1
UCEC	p62 Lck ligand →	+0.414	+2.179	.004	.034	3	1
UCEC	Rab25 →	-0.350	-3.169	.019	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

14-3-3_beta by C8orf58 expression — UCEC

Explore this box plot interactively →