C8orf58

Across TCGA pan-cancer cohorts, C8orf58 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated C8orf58 data layer compared with 3 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher C8orf58 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C8orf58 expression acts as an unfavorable survival marker, although some lineages such as UVM and ESCA show a favorable association.

MESO, ACC, and UVM are the cancer types where C8orf58 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.417	0.663	<.001	108	view →
ACC	DFS	Quartile	All	0.150	0.711	<.001	89	view →
UVM	DFS	Tertile	III,IV	0.815	0.242	<.001	58	view →
KIRP	DFS	Quartile	II,III,IV	0.226	0.854	.019	48	view →
BLCA	DFS	Tertile	All	0.233	0.617	.004	41	view →
ESCA	OS	Quartile	II,III,IV	0.798	0.400	.006	41	view →
LGG	DFS	Tertile	All	0.730	0.870	<.001	30	view →
THYM	DFS	Median	All	0.934	0.795	.005	20	view →
UCEC	OS	Quartile	II,III,IV	0.808	0.583	.016	18	view →
TGCT	DFS	Median	All	0.756	0.912	.010	14	view →
THCA	DFS	Median	All	0.935	0.667	.003	13	view →
KIRC	DFS	Median	II,III,IV	0.454	0.604	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

C8orf58–MESO (OS)

Open the MESO breakdown →