C8orf58

Across TCGA cell cohorts, C8orf58 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,750 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C8orf58-associated GO terms across cancer lineages are Peptidyl-lysine oxidation, Positive regulation of substrate adhesion-dependent cell spreading, and Positive regulation of cytoskeleton organization. Each is linked with C8orf58 in more than 12 cancer types. Because this analysis shows association rather than direction, both C8orf58-to-partner and partner-to-C8orf58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-lysine oxidation grouped by C8orf58-low versus C8orf58-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf58→partner) and Y-score (partner→C8orf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Peptidyl-lysine oxidation →	+1.157	+0.941	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Positive regulation of substrate adhesion-dependent cell spreading →	+0.110	+1.036	.002	.001	3	13
LUNG_NSCLC_LUSC	Positive regulation of cytoskeleton organization →	+0.080	+1.125	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Positive regulation of stress fiber assembly →	+0.158	+1.654	<.001	<.001	3	11
LUNG_SCLC	Regulation of substrate adhesion-dependent cell spreading →	+0.086	+0.956	<.001	.002	3	11
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.221	+1.201	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,750 associations by consensus.

Peptidyl-lysine oxidation by C8orf58 expression — LUNG_NSCLC_LUSC

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