C8orf58

Across TCGA cell cohorts, C8orf58 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C8orf58-associated genes across cancer lineages are C5orf52, AKAIN1, and OR10H5. Each is linked with C8orf58 in more than 1 cancer types. Because this analysis shows association rather than direction, both C8orf58-to-partner and partner-to-C8orf58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf52 grouped by C8orf58-low versus C8orf58-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf58→partner) and Y-score (partner→C8orf58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C5orf52 →	+0.018	+4.569	<.001	.003	3	1
BLOOD_Leukemia	AKAIN1 →	+0.043	+3.684	<.001	.004	3	1
SKIN	OR10H5 →	+0.012	+4.977	<.001	.007	3	1
SKIN	C16orf82 →	+0.016	+4.977	<.001	.007	3	1
BLOOD_Leukemia	SLC5A4 →	+0.359	+3.471	<.001	.004	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C5orf52 by C8orf58 expression — BLOOD_Leukemia

Explore this box plot interactively →