C8orf44-SGK3

Across TCGA pan-cancer cohorts, C8orf44-SGK3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C8orf44-SGK3 data layer compared with 29 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C8orf44-SGK3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated C8orf44-SGK3 expression acts as an unfavorable survival marker.

HNSC, LGG, and BLCA are the cancer types where C8orf44-SGK3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.187	0.710	.014	24	view →
LGG	OS	Median	All	0.316	0.830	.006	6	view →
BLCA	OS	Median	III,IV	0.201	0.579	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

C8orf44-SGK3–HNSC (DFS)

Open the HNSC breakdown →