C8orf34

Across TCGA patient cohorts, C8orf34 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C8orf34-associated genes across cancer lineages are PCNA, eIF4E, and A-Raf_pS299. Each is linked with C8orf34 in more than 2 cancer types. Because this analysis shows association rather than direction, both C8orf34-to-partner and partner-to-C8orf34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by C8orf34-low versus C8orf34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf34→partner) and Y-score (partner→C8orf34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.291	+3.807	<.001	<.001	3	3
UCEC	eIF4E →	+0.199	+3.598	.005	.001	3	3
LUSC	A-Raf_pS299 →	+0.296	+3.179	.016	.010	3	2
UCEC	eEF2 →	+0.392	+2.700	.001	.005	3	2
UCEC	FoxM1 →	+0.212	+1.807	.016	.004	3	2
UCEC	FOXO3a_pS318_S321 →	-0.132	-1.838	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

PCNA by C8orf34 expression — UCEC

Explore this box plot interactively →