C8orf34

Across TCGA pan-cancer cohorts, C8orf34 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated C8orf34 data layer compared with 6 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher C8orf34 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated C8orf34 expression acts as an unfavorable survival marker, although some lineages such as ACC and BRCA show a favorable association.

ACC, KICH, and LUSC are the cancer types where C8orf34 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.847	0.205	<.001	39	view →
KICH	DFS	Quartile	All	0.706	1.000	.002	36	view →
LUSC	DFS	Tertile	All	0.308	0.470	.010	31	view →
LGG	DFS	Median	All	0.771	0.873	.005	26	view →
BRCA	OS	Tertile	III,IV	0.894	0.722	<.001	22	view →
THCA	OS	Median	II,III,IV	0.958	0.792	.009	17	view →
LUAD	OS	Quartile	All	0.618	0.314	.006	14	view →
KIRP	DFS	Quartile	IV	0.049	0.687	.024	13	view →
UCS	DFS	Quartile	All	0.265	0.584	.020	10	view →
MESO	DFS	Tertile	III,IV	0.465	0.270	.005	9	view →
THYM	DFS	Median	II,III,IV	0.966	0.822	.008	8	view →
SARC	DFS	Median	All	0.435	0.587	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

C8orf34–ACC (DFS)

Open the ACC breakdown →