C8orf34

Across TCGA cell cohorts, C8orf34 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C8orf34-associated genes across cancer lineages are DEFB133, DEFB124, and OR56A5. Each is linked with C8orf34 in more than 1 cancer types. Because this analysis shows association rather than direction, both C8orf34-to-partner and partner-to-C8orf34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB133 grouped by C8orf34-low versus C8orf34-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf34→partner) and Y-score (partner→C8orf34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DEFB133 →	+0.023	+4.247	<.001	.004	3	2
BLOOD_Lymphoma	DEFB124 →	+0.090	+3.342	<.001	.008	3	1
BLOOD_Lymphoma	OR56A5 →	+0.047	+3.342	.005	.008	3	1
BLOOD_Lymphoma	OR6V1 →	+0.022	+4.584	<.001	<.001	3	1
BLOOD_Leukemia	MC3R →	+0.014	+4.984	<.001	.002	3	1
BLOOD_Leukemia	SMIM23 →	+0.018	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

DEFB133 by C8orf34 expression — BLOOD_Lymphoma

Explore this box plot interactively →