C8orf34-AS1

Across TCGA pan-cancer cohorts, C8orf34-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of C8orf34-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where C8orf34-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types C8orf34-AS1 is over-expressed in tumor, although a few such as LUAD and HNSC show the opposite, repressed pattern.

LUAD, HNSC, and KIRC are the cancer types where C8orf34-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C8orf34-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−3.455	<.001	11	view →
HNSC	All	III,IV	−0.596	<.001	10	view →
KIRC	All	All	−0.564	<.001	8	view →
LUSC	Male	II,III,IV	−3.831	<.001	7	view →
BRCA	All	III,IV	−0.897	<.001	6	view →
KICH	Female	II,III,IV	−1.012	.003	4	view →
COAD	All	II,III,IV	+0.076	.017	4	view →
PRAD	All	All	+1.223	<.001	2	view →
THCA	Female	All	+0.271	.001	2	view →
STAD	All	All	−0.158	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

C8orf34-AS1–LUAD

Open the LUAD breakdown →