chromosome 8 putative open reading frame 17Genealiases: MOST-1 · MOST1
Q-omics provides the consensus-scored C8orf17 profile across patient tissues and cancer cell-line models. C8orf17 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, C8orf17 is differentially expressed in 6, with the highest sampling consensus in KIRC. Additionally, C8orf17 RNA expression shows 8,641 significant gene co-expression associations, with the highest sampling consensus in LAML. Together, these results highlight KICH, KIRC, and LAML as cancer lineages where C8orf17 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C8orf17 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C8orf17 survival associations across molecular data types. C8orf17 RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C8orf17 RNA expression–survival associations across cancer types. High C8orf17 expression shows unfavorable associations in KICH, READ and UVM, but favorable associations in BLCA, UCS and CHOL. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for C8orf17 RNA expression.
This table summarizes C8orf17 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for C8orf17. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C8orf17 shows lower tumor expression in THCA and higher tumor expression in KIRC, BRCA, STAD, CHOL and HNSC. The KIRC box plot shows higher C8orf17 RNA expression in tumor versus normal tissue (log2 FC = +0.074, t-test p < 0.001).
This table shows molecular features associated with C8orf17 in patient tissues and cancer cell lines. In patient samples, C8orf17 shows the broadest associations at the RNA and protein expression levels, with LAML recurring as the lineage with the largest associated feature set. In cancer cell lines, C8orf17 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in NCI60_ALL.
