C8B

Across TCGA pan-cancer cohorts, C8B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated C8B data layer compared with 19 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher C8B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C8B expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

COAD, LUAD, and PDAC are the cancer types where C8B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.879	1.000	.019	48	view →
LUAD	OS	Tertile	II,III,IV	0.385	0.781	.002	34	view →
PDAC	OS	Median	II,III,IV	0.683	0.969	.001	29	view →
LSCC	DFS	Median	II,III,IV	0.830	1.000	.003	16	view →
CCRCC	DFS	Tertile	IV	0.961	0.199	.024	12	view →
GBM	OS	Quartile	All	0.246	0.556	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

C8B–COAD (DFS)

Open the COAD breakdown →