C8A

Across TCGA pan-cancer cohorts, C8A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated C8A data layer compared with 18 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher C8A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C8A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

COAD, LUAD, and PDAC are the cancer types where C8A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.879	1.000	.019	36	view →
LUAD	OS	Quartile	II,III,IV	0.463	0.869	.004	25	view →
PDAC	OS	Median	II,III,IV	0.679	0.973	<.001	25	view →
LSCC	DFS	Tertile	II,III,IV	0.765	1.000	.003	18	view →
CCRCC	DFS	Tertile	IV	0.961	0.199	.024	12	view →
GBM	DFS	Quartile	All	0.558	0.216	.026	3	view →
HNSC	DFS	Median	III,IV	0.992	0.913	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

C8A–COAD (DFS)

Open the COAD breakdown →