C8A

Across TCGA pan-cancer cohorts, C8A RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of C8A’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where C8A RNA is repressed in tumor relative to normal tissue. In most cancer types C8A is over-expressed in tumor, although a few such as LIHC and CHOL show the opposite, repressed pattern.

LIHC, CHOL, and THCA are the cancer types where C8A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C8A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	All	−2.379	<.001	9	view →
CHOL	Female	All	−6.496	<.001	5	view →
THCA	Female	All	+0.392	<.001	4	view →
LUSC	Male	II,III,IV	−0.312	<.001	4	view →
COAD	Male	II,III,IV	+0.015	.045	2	view →
LUAD	Male	II,III,IV	−0.376	.044	1	view →
KICH	Female	All	−0.074	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

C8A–LIHC

Open the LIHC breakdown →