C8A

Across TCGA patient cohorts, C8A mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C8A-associated genes across cancer lineages are HER3_pY1289, AMPK_alpha, and eIF4E. Each is linked with C8A in more than 1 cancer types. Because this analysis shows association rather than direction, both C8A-to-partner and partner-to-C8A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by C8A-low versus C8A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8A→partner) and Y-score (partner→C8A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	HER3_pY1289 →	+0.101	+3.331	.020	.005	3	2
LUAD	AMPK_alpha →	+0.277	+3.000	.001	.036	3	2
UCEC	eIF4E →	+0.151	+1.523	.025	.008	3	2
UCEC	JNK_pT183_Y185 →	-0.196	-2.321	<.001	<.001	3	2
UCEC	JNK2 →	+0.232	+2.672	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.175	-2.234	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

HER3_pY1289 by C8A expression — LUSC

Explore this box plot interactively →