C7orf57

Across TCGA patient cohorts, C7orf57 mutation is significantly associated with the RNA expression of many other genes, with 1,516 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C7orf57-associated genes across cancer lineages are BUB3, UTP15, and CDC40. Each is linked with C7orf57 in more than 2 cancer types. Because this analysis shows association rather than direction, both C7orf57-to-partner and partner-to-C7orf57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by C7orf57-low versus C7orf57-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C7orf57→partner) and Y-score (partner→C7orf57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.537	+2.397	<.001	.002	3	3
UCEC	UTP15 →	+0.390	+3.354	.004	.005	3	3
UCEC	CDC40 →	+0.518	+3.513	.007	.002	3	3
UCEC	DEPDC1 →	+0.744	+3.584	.001	.002	3	3
UCEC	CLSPN →	+0.761	+3.491	<.001	.002	3	3
UCEC	CDC7 →	+0.684	+2.098	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,516 associations by consensus.

BUB3 by C7orf57 expression — UCEC

Explore this box plot interactively →