C7orf57

Across TCGA pan-cancer cohorts, C7orf57 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated C7orf57 data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher C7orf57 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C7orf57 expression acts as an unfavorable survival marker, although some lineages such as SKCM and ESCA show a favorable association.

THCA, LGG, and STAD are the cancer types where C7orf57 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	II,III,IV	0.704	1.000	.001	71	view →
LGG	DFS	Median	All	0.654	0.815	<.001	54	view →
STAD	DFS	Quartile	II,III,IV	0.437	0.651	<.001	36	view →
UVM	DFS	Tertile	II,III,IV	0.312	0.620	.005	35	view →
SKCM	OS	Quartile	III,IV	0.517	0.236	.005	21	view →
GBM	OS	Quartile	All	0.376	0.678	.005	20	view →
COAD	DFS	Quartile	All	0.699	0.829	.003	20	view →
LIHC	DFS	Median	II,III,IV	0.297	0.553	.004	19	view →
ACC	OS	Median	III,IV	0.321	0.789	.011	15	view →
ESCA	OS	Median	III,IV	0.669	0.434	.013	14	view →
BLCA	DFS	Tertile	All	0.560	0.668	.014	13	view →
MESO	OS	Median	II,III,IV	0.333	0.712	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

C7orf57–THCA (OS)

Open the THCA breakdown →