C7orf57

Across TCGA patient cohorts, C7orf57 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C7orf57-associated genes across cancer lineages are eIF4E, FOXO3a_pS318_S321, and PDCD4. Each is linked with C7orf57 in more than 2 cancer types. Because this analysis shows association rather than direction, both C7orf57-to-partner and partner-to-C7orf57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by C7orf57-low versus C7orf57-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C7orf57→partner) and Y-score (partner→C7orf57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.249	+2.820	.004	.035	3	2
COAD	FOXO3a_pS318_S321 →	-0.182	-3.144	.024	.019	3	2
UCEC	PDCD4 →	-0.635	-1.906	<.001	.016	3	2
UCEC	FASN →	+0.402	+2.999	.011	.035	3	2
UCEC	mTOR_pS2448 →	-0.220	-4.169	<.001	<.001	3	2
UCEC	p21 →	+0.185	+3.183	.016	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

eIF4E by C7orf57 expression — COAD

Explore this box plot interactively →