C7orf50

Across TCGA patient cohorts, C7orf50 mutation is significantly associated with the RNA expression of many other genes, with 209 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible C7orf50-associated genes across cancer lineages are EEF1E1-BLOC1S5, RPL31P54, and PGBD4P5. Each is linked with C7orf50 in more than 1 cancer types. Because this analysis shows association rather than direction, both C7orf50-to-partner and partner-to-C7orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EEF1E1-BLOC1S5 grouped by C7orf50-low versus C7orf50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C7orf50→partner) and Y-score (partner→C7orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EEF1E1-BLOC1S5 →	+0.050	+4.132	<.001	.009	3	2
UCEC	RPL31P54 →	+0.164	+4.005	.006	.002	3	2
BLCA	PGBD4P5 →	+0.414	+6.018	<.001	.002	3	2
BLCA	RN7SL156P →	+0.488	+4.973	<.001	.009	3	2
BRCA	MIR6879 →	+0.500	+8.055	<.001	.007	3	1
BRCA	RNA5SP26 →	+0.317	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 209 associations by consensus.

EEF1E1-BLOC1S5 by C7orf50 expression — UCEC

Explore this box plot interactively →