C7orf50

Across TCGA pan-cancer cohorts, C7orf50 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C7orf50’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where C7orf50 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C7orf50 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where C7orf50 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C7orf50 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.981	<.001	11	view →
HNSC	Male	III,IV	+0.981	<.001	10	view →
LIHC	Female	II,III,IV	+1.408	<.001	8	view →
KIRP	Male	II,III,IV	+0.383	.023	7	view →
BRCA	All	III,IV	+0.656	<.001	6	view →
KICH	All	All	−0.607	<.001	6	view →
STAD	All	II,III,IV	+0.655	.004	4	view →
CHOL	Male	All	+1.815	<.001	3	view →
ESCA	All	All	+0.836	.003	3	view →
KIRC	All	III,IV	+0.282	.004	3	view →
PRAD	All	All	−0.298	.004	2	view →
LUAD	All	III,IV	+0.525	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C7orf50–COAD

Open the COAD breakdown →