C7orf33

Across TCGA patient cohorts, C7orf33 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C7orf33-associated genes across cancer lineages are ERK2, FOXO3a_pS318_S321, and MEK1. Each is linked with C7orf33 in more than 1 cancer types. Because this analysis shows association rather than direction, both C7orf33-to-partner and partner-to-C7orf33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by C7orf33-low versus C7orf33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C7orf33→partner) and Y-score (partner→C7orf33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.295	+3.169	.005	.020	3	1
UCEC	FOXO3a_pS318_S321 →	-0.139	-3.169	.043	.020	3	1
UCEC	MEK1 →	+0.555	+3.169	.005	.020	2	1
UCEC	ATM →	-0.934	-3.169	<.001	.020	1	2
UCEC	eIF4E →	+0.259	+3.169	.025	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ERK2 by C7orf33 expression — UCEC

Explore this box plot interactively →