C7orf31

Across TCGA patient cohorts, C7orf31 mutation is significantly associated with the RNA expression of many other genes, with 3,576 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C7orf31-associated genes across cancer lineages are FANCM, CTNNAL1, and LIAS. Each is linked with C7orf31 in more than 2 cancer types. Because this analysis shows association rather than direction, both C7orf31-to-partner and partner-to-C7orf31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCM grouped by C7orf31-low versus C7orf31-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C7orf31→partner) and Y-score (partner→C7orf31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FANCM →	+0.628	+3.328	.004	.005	3	3
UCEC	CTNNAL1 →	+0.663	+1.828	<.001	.002	3	3
UCEC	LIAS →	+0.346	+3.754	.003	<.001	3	3
UCEC	PAICS →	+0.613	+3.917	<.001	<.001	3	3
UCEC	PPID →	+0.701	+2.534	<.001	<.001	3	3
UCEC	EIF2B3 →	+0.353	+2.279	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,576 associations by consensus.

FANCM by C7orf31 expression — SKCM

Explore this box plot interactively →