C7orf31

Across TCGA pan-cancer cohorts, C7orf31 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated C7orf31 data layer compared with 5 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher C7orf31 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C7orf31 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

LGG, KICH, and KIRC are the cancer types where C7orf31 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.363	0.538	<.001	53	view →
KICH	DFS	Quartile	II,III,IV	0.534	1.000	.001	52	view →
KIRC	DFS	Quartile	II,III,IV	0.803	0.498	.002	48	view →
SCLC	OS	Quartile	II,III,IV	0.629	0.225	.002	47	view →
SKCM	DFS	Median	II,III,IV	0.760	0.619	.001	45	view →
KIRP	OS	Median	II,III,IV	0.906	0.733	.009	40	view →
READ	DFS	Tertile	All	0.849	0.411	.004	31	view →
LIHC	OS	Median	III,IV	0.437	0.741	.005	24	view →
MESO	OS	Median	IV	0.762	0.349	.010	21	view →
PAAD	DFS	Quartile	All	0.399	0.174	.004	18	view →
STAD	DFS	Median	All	0.313	0.464	.006	18	view →
GBM	OS	Quartile	All	0.250	0.433	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

C7orf31–LGG (OS)

Open the LGG breakdown →