C7orf31

Across TCGA patient cohorts, C7orf31 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C7orf31-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and Ku80. Each is linked with C7orf31 in more than 1 cancer types. Because this analysis shows association rather than direction, both C7orf31-to-partner and partner-to-C7orf31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by C7orf31-low versus C7orf31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C7orf31→partner) and Y-score (partner→C7orf31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.090	-3.432	.019	.005	3	2
UCEC	EGFR_pY1068 →	-0.304	-3.247	.001	<.001	3	2
UCEC	Ku80 →	+0.313	+2.598	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.152	-2.571	.007	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.696	+3.720	.002	<.001	3	2
UCEC	4E-BP1 →	+0.339	+3.459	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

14-3-3_beta by C7orf31 expression — UCEC

Explore this box plot interactively →