C7orf25

Across TCGA pan-cancer cohorts, C7orf25 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of C7orf25’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where C7orf25 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types C7orf25 is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where C7orf25 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C7orf25 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−0.175	<.001	6	view →
LUAD	Male	All	−0.169	<.001	6	view →
LSCC	Male	All	−0.095	<.001	4	view →
HNSC	Male	III,IV	+0.119	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

C7orf25–CCRCC

Open the CCRCC breakdown →