C6orf223

Across TCGA patient cohorts, C6orf223 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C6orf223-associated genes across cancer lineages are SNORD115-45, RN7SKP181, and RN7SKP172. Each is linked with C6orf223 in more than 1 cancer types. Because this analysis shows association rather than direction, both C6orf223-to-partner and partner-to-C6orf223 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD115-45 grouped by C6orf223-low versus C6orf223-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C6orf223→partner) and Y-score (partner→C6orf223) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD115-45 →	+0.662	+5.186	<.001	.007	3	2
UCEC	RN7SKP181 →	+0.219	+5.133	.003	.008	3	2
UCEC	RN7SKP172 →	+0.326	+5.551	<.001	.004	3	2
COAD	MIR8073 →	+0.839	+6.392	<.001	.001	3	2
LUSC	MIR1911 →	+0.678	+7.924	<.001	.008	3	2
SKCM	FECHP1 →	+0.032	+5.199	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

SNORD115-45 by C6orf223 expression — UCEC

Explore this box plot interactively →