Across TCGA patient cohorts, C6orf141 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C6orf141-associated genes across cancer lineages are EGFR_pY1068, p70-S6K_pT389, and Annexin-1. Each is linked with C6orf141 in more than 1 cancer types. Because this analysis shows association rather than direction, both C6orf141-to-partner and partner-to-C6orf141 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C6orf141→partner) and Y-score (partner→C6orf141) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.365	-3.321	.005	.010	3	1
UCEC	p70-S6K_pT389 →	-0.287	-2.999	.004	.035	3	1
UCEC	Annexin-1 →	+0.861	+3.321	.001	.010	3	1
UCEC	Shc_pY317 →	-0.294	-3.321	<.001	.010	3	1
UCEC	Caspase-8 →	-0.330	-3.143	.012	.018	3	1
UCEC	JNK2 →	+0.333	+2.817	.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

C6orf141 survival (RNA) · tumor vs normal (RNA) · all C6orf141 data types