C6orf118

Across TCGA patient cohorts, C6orf118 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C6orf118-associated genes across cancer lineages are PCNA, mTOR_pS2448, and 4E-BP1_pT70. Each is linked with C6orf118 in more than 3 cancer types. Because this analysis shows association rather than direction, both C6orf118-to-partner and partner-to-C6orf118 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by C6orf118-low versus C6orf118-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C6orf118→partner) and Y-score (partner→C6orf118) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.344	+2.938	<.001	<.001	3	4
LUSC	mTOR_pS2448 →	-0.349	-3.557	<.001	.002	3	3
UCEC	4E-BP1_pT70 →	+0.109	+2.321	.006	.033	3	3
UCEC	C-Raf →	+0.227	+2.070	<.001	.001	3	3
UCEC	Cyclin-E2 →	+0.144	+1.440	.014	.024	3	3
SKCM	BRCA2 →	-0.157	-3.299	.022	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

PCNA by C6orf118 expression — UCEC

Explore this box plot interactively →