C6

Across TCGA patient cohorts, C6 protein abundance is significantly associated with the RNA expression of many other genes, with 14,763 significant associations in total. COAD shows the largest number of these associations.

The most reproducible C6-associated genes across cancer lineages are SERPINE1, MMP19, and ADAMTS4. Each is linked with C6 in more than 8 cancer types. Because this analysis shows association rather than direction, both C6-to-partner and partner-to-C6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C6 versus SERPINE1 in GBM, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C6→partner) and Y-score (partner→C6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SERPINE1 →	+1.746	+0.896	<.001	<.001	3	9
GBM	MMP19 →	+1.214	+0.659	<.001	<.001	3	9
GBM	ADAMTS4 →	+1.149	+0.650	<.001	.001	3	8
COAD	ITGA5 →	+0.986	+0.531	<.001	<.001	3	8
BRCA	SEMA6B →	+0.868	+0.539	<.001	<.001	3	8
COAD	SLC2A3 →	+1.047	+0.519	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,763 associations by consensus.

C6 vs SERPINE1 — GBM

Explore this scatter interactively →