C6

Across TCGA pan-cancer cohorts, C6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of C6’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where C6 RNA is repressed in tumor relative to normal tissue. In most cancer types C6 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and LUSC are the cancer types where C6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−1.280	<.001	11	view →
LUAD	All	III,IV	−1.975	<.001	9	view →
LUSC	Female	II,III,IV	−2.591	<.001	8	view →
LIHC	Female	All	−2.160	<.001	8	view →
HNSC	Male	All	−0.702	<.001	8	view →
BLCA	All	III,IV	−0.647	<.001	8	view →
COAD	Female	II,III,IV	−0.608	<.001	8	view →
UCEC	All	All	−1.908	.002	6	view →
BRCA	All	III,IV	−1.558	<.001	6	view →
CHOL	All	All	−4.983	<.001	5	view →
KIRC	Male	All	+0.668	.006	3	view →
KIRP	All	All	+1.269	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

C6–THCA

Open the THCA breakdown →