C6

Across TCGA cell cohorts, C6 RNA expression is significantly associated with the go_rna of many other GO terms, with 864 significant associations in total. BONE shows the largest number of these associations.

The most reproducible C6-associated GO terms across cancer lineages are Hepatocyte growth factor receptor signaling pathway, MHC class I protein complex assembly, and Peptide antigen assembly with MHC class I protein complex. Each is linked with C6 in more than 3 cancer types. Because this analysis shows association rather than direction, both C6-to-partner and partner-to-C6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hepatocyte growth factor receptor signaling pathway grouped by C6-low versus C6-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C6→partner) and Y-score (partner→C6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Hepatocyte growth factor receptor signaling pathway →	+0.182	+0.068	<.001	.004	3	4
BREAST	MHC class I protein complex assembly →	+0.107	+0.057	.007	.007	3	4
BREAST	Peptide antigen assembly with MHC class I protein complex →	+0.107	+0.057	.007	.007	3	4
KIDNEY	Regulation of lipoprotein transport →	+0.164	+0.121	<.001	.005	3	4
KIDNEY	Positive regulation of lipoprotein transport →	+0.164	+0.121	<.001	.005	3	4
BREAST	Negative regulation of T cell differentiation →	+0.149	+0.090	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 864 associations by consensus.

Hepatocyte growth factor receptor signaling pathway by C6 expression — BREAST

Explore this box plot interactively →