C6

Across TCGA cell cohorts, C6 mutation is significantly associated with the RNA expression of many other genes, with 180 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C6-associated genes across cancer lineages are C1orf146, MT1HL1, and PFN3. Each is linked with C6 in more than 1 cancer types. Because this analysis shows association rather than direction, both C6-to-partner and partner-to-C6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf146 grouped by C6-low versus C6-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C6→partner) and Y-score (partner→C6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C1orf146 →	+0.033	+4.044	<.001	.003	3	2
LUNG_NSCLC_LUAD	MT1HL1 →	+0.074	+3.944	<.001	.006	3	2
STOMACH	PFN3 →	+0.164	+3.209	.003	.007	3	2
BREAST	KRTAP10-10 →	+0.036	+5.169	<.001	.005	3	2
LUNG_SCLC	BIN2 →	+0.063	+3.447	<.001	.002	3	2
BLOOD_Lymphoma	OR9I1 →	+0.086	+4.523	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 180 associations by consensus.

C1orf146 by C6 expression — CNS

Explore this box plot interactively →