C5orf66-AS1

Across TCGA pan-cancer cohorts, C5orf66-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated C5orf66-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher C5orf66-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C5orf66-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

ACC, HNSC, and KICH are the cancer types where C5orf66-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.417	0.863	<.001	118	view →
HNSC	OS	Tertile	All	0.825	0.662	<.001	112	view →
KICH	OS	Tertile	II,III,IV	0.226	0.861	<.001	87	view →
SKCM	OS	Tertile	All	0.159	0.359	<.001	57	view →
KIRC	DFS	Tertile	III,IV	0.479	0.753	.027	48	view →
DLBC	OS	Quartile	IV	0.172	0.822	.008	28	view →
TGCT	DFS	Median	All	0.525	0.815	.001	14	view →
CESC	DFS	Median	All	0.876	0.769	.006	14	view →
READ	OS	Tertile	III,IV	1.000	0.606	.007	11	view →
KIRP	OS	Tertile	All	0.770	0.926	.021	9	view →
BRCA	OS	Median	IV	0.189	0.628	.009	6	view →
COAD	OS	Median	IV	0.368	0.779	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

C5orf66-AS1–ACC (OS)

Open the ACC breakdown →