C5orf66-AS1

Across TCGA pan-cancer cohorts, C5orf66-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C5orf66-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C5orf66-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types C5orf66-AS1 is over-expressed in tumor, although a few such as HNSC and BLCA show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where C5orf66-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C5orf66-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	−3.647	<.001	12	view →
BLCA	Male	IV	−3.417	<.001	11	view →
COAD	Male	All	−0.865	<.001	11	view →
LUSC	Female	All	+2.243	<.001	8	view →
STAD	Male	II,III,IV	−2.402	<.001	6	view →
BRCA	All	All	+0.881	<.001	6	view →
READ	Male	All	−1.323	.002	5	view →
LUAD	All	All	+0.375	<.001	5	view →
UCEC	All	All	+0.628	.009	2	view →
PRAD	All	All	−0.602	<.001	2	view →
PAAD	Female	All	+0.550	.020	2	view →
LIHC	All	All	+0.118	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C5orf66-AS1–HNSC

Open the HNSC breakdown →