Across TCGA pan-cancer cohorts, C5orf49 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated C5orf49 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher C5orf49 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated C5orf49 expression acts as an unfavorable survival marker.

LSCC and LUAD are the cancer types where C5orf49 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.541	0.888	.013	14	view →
LUAD	DFS	Median	III,IV	0.438	1.000	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: C5orf49 tumor-vs-normal RNA expression · all C5orf49 data types