Across TCGA pan-cancer cohorts, C5orf49 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of C5orf49’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where C5orf49 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C5orf49 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.
KIRC, THCA, and LUSC are the cancer types where C5orf49 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C5orf49 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.