C5orf49

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, C5orf49 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5orf49-associated genes across cancer lineages are p62 Lck ligand, YAP, and EGFR. Each is linked with C5orf49 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf49-to-partner and partner-to-C5orf49 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf49→partner) and Y-score (partner→C5orf49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECp62 Lck ligand →+0.405+3.000.031.03731
UCECYAP →+0.200+2.817.021.03621
UCECEGFR →-0.255-3.000.005.03711
UCECJNK_pT183_Y185 →-0.215-2.986.027.03711
UCECMEK1 →+0.511+3.000.015.03711
UCECmTOR_pS2448 →-0.177-3.000.040.03711
Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration