C5orf46

Across TCGA cell cohorts, C5orf46 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,252 significant associations in total. BONE shows the largest number of these associations.

The most reproducible C5orf46-associated GO terms across cancer lineages are Positive regulation of blood pressure by epinephrine-norepinephrine, Blood coagulation, fibrin clot formation, and Substrate adhesion-dependent cell spreading. Each is linked with C5orf46 in more than 10 cancer types. Because this analysis shows association rather than direction, both C5orf46-to-partner and partner-to-C5orf46 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of blood pressure by epinephrine-norepinephrine grouped by C5orf46-low versus C5orf46-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf46→partner) and Y-score (partner→C5orf46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of blood pressure by epinephrine-norepinephrine →	+0.547	+2.619	<.001	<.001	3	11
BREAST	Blood coagulation, fibrin clot formation →	+0.444	+1.955	<.001	<.001	3	10
LIVER	Substrate adhesion-dependent cell spreading →	+0.224	+3.422	<.001	.007	3	10
BONE	Wound healing →	+0.139	+2.760	<.001	<.001	3	9
CNS	Epiboly →	+0.174	+2.947	<.001	<.001	3	9
BONE	Epiboly involved in wound healing →	+0.201	+3.019	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,252 associations by consensus.

Positive regulation of blood pressure by epinephrine-norepinephrine by C5orf46 expression — BONE

Explore this box plot interactively →