Across TCGA pan-cancer cohorts, C5orf38 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C5orf38 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher C5orf38 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated C5orf38 expression acts as an unfavorable survival marker.

HNSC, LIHC, and LUAD are the cancer types where C5orf38 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.235	0.686	.027	15	view →
LIHC	DFS	Median	All	0.020	0.554	<.001	12	view →
LUAD	OS	Median	All	0.276	0.697	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: C5orf38 tumor-vs-normal RNA expression · all C5orf38 data types