Across TCGA patient cohorts, C5orf38 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5orf38-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with C5orf38 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf38-to-partner and partner-to-C5orf38 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf38→partner) and Y-score (partner→C5orf38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.117	-3.295	.004	.009	3	1
UCEC	eEF2 →	+0.428	+3.169	.003	.018	3	1
UCEC	EGFR_pY1068 →	-0.328	-2.115	.001	.017	3	1
UCEC	JNK2 →	+0.252	+2.009	.002	.017	3	1
UCEC	Ku80 →	+0.227	+3.013	.019	<.001	3	1
UCEC	MSH2 →	-0.189	-2.295	.046	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

C5orf38 survival (RNA) · tumor vs normal (RNA) · all C5orf38 data types