C5orf34

Across TCGA cell cohorts, C5orf34 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C5orf34-associated genes across cancer lineages are EPPIN, OR3A1, and FIGLA. Each is linked with C5orf34 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf34-to-partner and partner-to-C5orf34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPPIN grouped by C5orf34-low versus C5orf34-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf34→partner) and Y-score (partner→C5orf34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	OR3A1 →	+1.055	+4.922	<.001	.009	3	1
BLOOD_Leukemia	FIGLA →	+0.036	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	SLC22A12 →	+0.006	+5.539	<.001	.003	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR1D4 →	+0.052	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EPPIN by C5orf34 expression — BLOOD_Leukemia

Explore this box plot interactively →