C5orf34-AS1

Across TCGA pan-cancer cohorts, C5orf34-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C5orf34-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where C5orf34-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types C5orf34-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, LUSC, and KIRP are the cancer types where C5orf34-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C5orf34-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+3.079	<.001	12	view →
LUSC	Female	II,III,IV	+2.469	<.001	8	view →
KIRP	All	II,III,IV	+0.679	.003	8	view →
KICH	Male	All	−0.460	<.001	8	view →
LIHC	All	All	+0.201	<.001	8	view →
THCA	Female	II,III,IV	−0.625	<.001	7	view →
COAD	All	All	+0.166	.008	5	view →
STAD	All	All	+0.616	.001	4	view →
BRCA	All	III,IV	+0.178	.024	4	view →
CHOL	All	All	+0.687	.001	2	view →
READ	Female	All	+0.512	.014	2	view →
BLCA	Male	All	+0.457	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C5orf34-AS1–HNSC

Open the HNSC breakdown →