C5AR2

Across TCGA patient cohorts, C5AR2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,448 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible C5AR2-associated genes across cancer lineages are SLC39A8, CDCA5, and TP53INP1. Each is linked with C5AR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5AR2-to-partner and partner-to-C5AR2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, C5AR2 versus SLC39A8 in LUAD, with a Pearson correlation of -0.78.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5AR2→partner) and Y-score (partner→C5AR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC39A8 →	-2.056	-1.296	.004	<.001	3	2
LSCC	CDCA5 →	+1.078	+0.536	.004	.002	3	2
LSCC	TP53INP1 →	-0.854	-0.424	.004	.006	3	2
LSCC	VDAC1 →	+0.612	+0.700	<.001	<.001	3	2
PDAC	RN7SL356P →	-0.729	-0.593	.006	<.001	3	2
LSCC	MFNG →	-0.914	-0.637	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,448 associations by consensus.

C5AR2 vs SLC39A8 — LUAD

Explore this scatter interactively →