C5AR2

Across TCGA patient cohorts, C5AR2 mutation is significantly associated with the RNA expression of many other genes, with 1,655 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5AR2-associated genes across cancer lineages are RNA5SP34, EME1, and ENTR1. Each is linked with C5AR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both C5AR2-to-partner and partner-to-C5AR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP34 grouped by C5AR2-low versus C5AR2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5AR2→partner) and Y-score (partner→C5AR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP34 →	+0.112	+4.110	<.001	.005	3	3
UCEC	EME1 →	+0.657	+3.917	.002	<.001	3	2
UCEC	ENTR1 →	+0.502	+3.475	.001	.002	3	2
UCEC	RNA5SP411 →	+1.646	+3.130	<.001	<.001	3	2
SKCM	NOC2LP1 →	+1.395	+2.534	<.001	.009	3	2
CESC	UBE2V1P4 →	+0.181	+5.103	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,655 associations by consensus.

RNA5SP34 by C5AR2 expression — SKCM

Explore this box plot interactively →