C5AR2

Across TCGA cell cohorts, C5AR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,774 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C5AR2-associated GO terms across cancer lineages are Cellular response to monosaccharide stimulus, Cellular response to hexose stimulus, and Regulation of insulin-like growth factor receptor signaling pathway. Each is linked with C5AR2 in more than 5 cancer types. Because this analysis shows association rather than direction, both C5AR2-to-partner and partner-to-C5AR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to monosaccharide stimulus grouped by C5AR2-low versus C5AR2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C5AR2→partner) and Y-score (partner→C5AR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cellular response to monosaccharide stimulus →	+0.101	+0.193	<.001	<.001	3	6
LUNG_SCLC	Cellular response to hexose stimulus →	+0.165	+0.173	<.001	<.001	3	6
BREAST	Regulation of insulin-like growth factor receptor signaling pathway →	+0.159	+2.126	<.001	<.001	3	6
LIVER	Intracellular receptor signaling pathway →	+0.042	+0.065	<.001	.002	3	5
LUNG_SCLC	Intracellular glucose homeostasis →	+0.083	+0.176	<.001	<.001	3	5
BLOOD_Leukemia	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.063	+0.863	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,774 associations by consensus.

Cellular response to monosaccharide stimulus by C5AR2 expression — LUNG_SCLC

Explore this box plot interactively →