C5AR2

Across TCGA cell cohorts, C5AR2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C5AR2-associated genes across cancer lineages are ACER1, WDR87, and GML. Each is linked with C5AR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5AR2-to-partner and partner-to-C5AR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by C5AR2-low versus C5AR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5AR2→partner) and Y-score (partner→C5AR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.136	+4.145	<.001	.001	3	1
LARGE_INTESTINE	WDR87 →	+0.021	+3.453	<.001	.009	3	1
BLOOD_Leukemia	GML →	+0.099	+4.152	<.001	.009	3	1
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CRYGC →	+0.026	+4.969	<.001	.003	3	1
BLOOD_Leukemia	SLC35G3 →	+0.062	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ACER1 by C5AR2 expression — LARGE_INTESTINE

Explore this box plot interactively →