C5

Across TCGA cell cohorts, C5 mutation is significantly associated with the RNA expression of many other genes, with 448 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C5-associated genes across cancer lineages are C19orf44, FAM149A, and SLC25A35. Each is linked with C5 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5-to-partner and partner-to-C5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C19orf44 grouped by C5-low versus C5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5→partner) and Y-score (partner→C5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C19orf44 →	+0.502	+3.237	<.001	.003	3	2
LARGE_INTESTINE	FAM149A →	+1.316	+2.628	<.001	.002	3	2
LARGE_INTESTINE	SLC25A35 →	+0.881	+3.389	<.001	.001	3	2
LARGE_INTESTINE	KMT5C →	+0.639	+3.743	.006	<.001	3	2
LARGE_INTESTINE	PGGT1B →	+0.649	+3.339	.008	.001	3	2
LARGE_INTESTINE	WDR87 →	+0.017	+2.616	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 448 associations by consensus.

C19orf44 by C5 expression — LARGE_INTESTINE

Explore this box plot interactively →