C4orf54

Across TCGA patient cohorts, C4orf54 mutation is significantly associated with the RNA expression of many other genes, with 764 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C4orf54-associated genes across cancer lineages are RNA5SP369, SAR1AP3, and RNA5SP436. Each is linked with C4orf54 in more than 1 cancer types. Because this analysis shows association rather than direction, both C4orf54-to-partner and partner-to-C4orf54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP369 grouped by C4orf54-low versus C4orf54-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C4orf54→partner) and Y-score (partner→C4orf54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP369 →	+0.313	+4.539	<.001	.008	3	2
CESC	SAR1AP3 →	+0.096	+4.874	<.001	.002	3	2
UCEC	RNA5SP436 →	+0.482	+3.200	<.001	.006	3	2
SARC	COX6B1P2 →	+0.279	+4.225	.002	.003	3	1
SARC	RPS23P3 →	+0.329	+4.225	<.001	.003	3	1
SARC	CCDC34P1 →	+0.079	+5.813	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 764 associations by consensus.

RNA5SP369 by C4orf54 expression — CESC

Explore this box plot interactively →